Our Research

Lee Y, Ju B, Cheon Y, Mishra N, Fletcher E, Koutakis P, Javan GT, Jang YC.Molecular mechanisms of exercise-induced neuroprotection against Parkinson'sdisease. Sports Med Health Sci. 2025 May 30;8(1):3-22. doi:10.1016/j.smhs.2025.05.004. PMID: 41646181; PMCID: PMC12869058.

 

Miserlis D, Ferrer L, Davies MG, Koutakis P. Hybrid superficial venousarterialization limb salvage for "full metal jacket" peripheral arterialstenting and no-option chronic limb-threatening ischemia: A case report. SciProg. 2025 Oct-Dec;108(4):368504251401247. doi: 10.1177/00368504251401247. Epub2025 Nov 28. PMID: 41313375; PMCID: PMC12663053.

 

Koutakis P, Fletcher E, Papoutsi E, Bohannon WT, Pipinos II, Miserlis D,Pacher P. Heavy alcohol use exacerbates skeletal myopathy in peripheral arterydisease. Geroscience. 2025 Nov 12. doi: 10.1007/s11357-025-01965-3. Epub aheadof print. PMID: 41219664.

 

Brown LP, Joshi J, Kosmac K, Long DE, Scott L, El-Amouri S, Montgomery-YatesAA, Kalema AG, Sturgill JL, Vekaria H, Sullivan PG, Wilburn D, Koutakis P,Latham CM, Fry CS, Kern PA, Miller BF, Dupont-Versteegden EE, Ismaeel A, MayerKP, Wen Y. Soluble IL-2R: A potential therapeutic target for mitochondrialdysfunction in post-COVID fatigue syndrome. Clin Transl Med. 2025Oct;15(10):e70507. doi: 10.1002/ctm2.70507. PMID: 41078008; PMCID: PMC12516084.

 

Wyse JM, Lopez P, Miserlis D, Koutakis P, Wechsler ME. Delivery of NucleicAcids for Vascular Tissue Engineering Applications. Regen Eng Transl Med. 2025May 12:10.1007/s40883-025-00421-0. doi: 10.1007/s40883-025-00421-0. Epub aheadof print. PMID: 41041154; PMCID: PMC12486593.

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Ismaeel A, Fletcher E, Papoutsi E, Thomas NT, Bohannon WT, Pipinos II, Wen Y,Miserlis D, Koutakis P. Multiomics Analysis of Skeletal Muscle IdentifiesDysregulation of Hypoxia-Induced Genes in Peripheral Artery Disease. J Am HeartAssoc. 2025 Oct 7;14(19):e042350. doi: 10.1161/JAHA.125.042350. Epub 2025 Sep30. PMID: 41025488; PMCID: PMC12684623.

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Tian Y, Hakim AH, Anderson CP, Sharma P, Al-Gahmi AM, Kim KS, Park SY,Koutakis P, Sachdev U, Draghici AE, Bagher P, Carlson MA, Pipinos II. InsightsFrom Bone and Muscle Oxygenation Toward a More Comprehensive Model of TissueHealing. J Surg Res. 2025 Nov;315:59-69. doi: 10.1016/j.jss.2025.08.015. Epub2025 Sep 23. PMID: 40992074; PMCID: PMC12551740.

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Ferrer L, Malin L, Koutakis P, Miserlis D. A 5-year limb salvage for long-term limb salvage in chronic limb-threatening ischemia without options forrevascularization, utilizing a hybrid deep venous arterialization technique: Acase report. Sci Prog. 2025 Apr-Jun;108(2):368504251352033. doi:10.1177/00368504251352033. Epub 2025 Jun 25. PMID: 40566874; PMCID: PMC12202888.

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Wilkinson T, Fletcher E, Ring A, Bradley C, Papoutsi E, Miserlis D, Smith RS,Bohannon WT, Pipinos II, Koutakis P. Deciphering the Role of Ferroptosis in thePathogenesis of Peripheral Artery Disease Myopathy. Biology (Basel). 2025 May12;14(5):537. doi: 10.3390/biology14050537. PMID: 40427725; PMCID: PMC12108827.

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Hoffmann C, Foster D, Fletcher E, Sasaki M, Li F, McLaughlin D, Cui X,Koutakis P, Call JA, Brewster L. Structured Exercise Therapy IncreasesEndogenous Antioxidants to Repair Muscle Strength and Health in Porcine IschemicMyopathy Model of Peripheral Artery Disease. Adv Wound Care (New Rochelle). 2025Sep;14(9):450-466. doi: 10.1089/wound.2024.0053. Epub 2025 Feb 5. PMID:39906922.

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Fletcher E, Miserlis D, Papoutsi E, Steiner JL, Gordon B, Haynatzki G,Pacher P, Koutakis P. Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model ofperipheral artery disease. Biochim Biophys Acta Mol Basis Dis. 2025Feb;1871(2):167584. doi: 10.1016/j.bbadis.2024.167584. Epub 2024 Nov 23. PMID:39581559; PMCID: PMC11931404.

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Wilburn D, Fletcher E, Papoutsi E, Bohannon WT, Haynatzki G, Zechmann B,Tian Y, Pipinos II, Miserlis D, Koutakis P. Ultrastructural alterations andmitochondrial dysfunction in skeletal muscle of peripheral artery diseasepatients: implications for early therapeutic interventions. EXCLI J. 2024 Oct7;23:1208-1225. doi: 10.17179/excli2024-7592. PMID: 39574966; PMCID:PMC11579521.

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Hanson NJ, Maceri RM, Koutakis P. Transcranial direct current stimulation(tDCS) and cycling performance on the 3-minute aerobic test (3mAT): placebo andnocebo effects. Sci Rep. 2024 Oct 21;14(1):24659. doi:10.1038/s41598-024-74941-0. PMID: 39428389; PMCID: PMC11491469.

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Wilburn D, Miserlis D, Fletcher E, Papoutsi E, Ismaeel A, Bradley C, Ring A,Wilkinson T, Smith RS, Ferrer L, Haynatzki G, Monteleone P, Banerjee S, BrisboisE, Bohannon WT, Koutakis P. Skeletal muscle desmin alterations followingrevascularization in peripheral artery disease claudicants. Sci Rep. 2024 Jun1;14(1):12609. doi: 10.1038/s41598-024-63626-3. PMID: 38824194; PMCID:PMC11144188.

 

Bradley CE, Fletcher E, Wilkinson T, Ring A, Ferrer L, Miserlis D, Pacher P,Koutakis P. Mitochondrial fatty acid beta-oxidation: a possible therapeutictarget for skeletal muscle lipotoxicity in peripheral artery disease myopathy.EXCLI J. 2024 Apr 23;23:523-533. doi: 10.17179/excli2024-7004. PMID: 38741727;PMCID: PMC11089102.

 

Koutakis P, Hernandez H, Miserlis D, Thompson JR, Papoutsi E, Mietus CJ,Haynatzki G, Kim JK, Casale GP, Pipinos II. Oxidative damage in thegastrocnemius predicts long-term survival in patients with peripheral arterydisease. NPJ Aging. 2024 Apr 5;10(1):21. doi: 10.1038/s41514-024-00147-3. PMID:38580664; PMCID: PMC10997596.

 

Tice AL, Gordon BS, Fletcher E, McNeill AG, Laskin GR, Laudato JA, RossettiML, Koutakis P, Steiner JL. Effects of chronic alcohol intoxication on aerobicexercise-induced adaptations in female mice. J Appl Physiol (1985). 2024 Apr1;136(4):721-738. doi: 10.1152/japplphysiol.00599.2023. Epub 2024 Feb 15. PMID:38357729; PMCID: PMC11286275.

 

Rahman H, Leutzinger T, Hassan M, Schieber M, Koutakis P, Fuglestad MA,DeSpiegelaere H, Longo GM, Malcolm P, Johanning JM, Casale GP, Pipinos II, MyersSA. Peripheral artery disease causes consistent gait irregularities regardlessof the location of leg claudication pain. Ann Phys Rehabil Med. 2024Apr;67(3):101793. doi: 10.1016/j.rehab.2023.101793. Epub 2023 Dec 20. PMID:38118246; PMCID: PMC11009086.

 

Chapman-Lopez TJ, Funderburk LK, Heileson JL, Wilburn DT, Koutakis P,Gallucci AR, Forsse JS. Effects of L-Leucine Supplementation and ResistanceTraining on Adipokine Markers in Untrained Perimenopausal and PostmenopausalWomen. J Strength Cond Res. 2024 Mar 1;38(3):526-532. doi:10.1519/JSC.0000000000004661. Epub 2023 Dec 13. PMID: 38088883.

 

Forsse JS, Richardson KA, Torres R, Lowry C, Taylor JK, Beeson CL, Ward J,Dhillon A, Niceler B, Ismaeel A, Koutakis P. Exploring an Unknown Corner of aWell-Known Topic: HIIE Influence on Renal Health and Filtration in HealthyIndividuals Free of Cardiometabolic Diseases. Sports (Basel). 2023 Oct30;11(11):210. doi: 10.3390/sports11110210. PMID: 37999427; PMCID: PMC10675315.

 

Cullen AE, Centner AM, Deitado R, Ismaeel A, Koutakis P, Muller-Delp J,Salazar G. AKT Mediates Adiponectin-Dependent Regulation of VSMC Phenotype.Cells. 2023 Oct 20;12(20):2493. doi: 10.3390/cells12202493. PMID: 37887338;PMCID: PMC10605922.

 

Tsai S, Liu Y, Hoang L, Vu M, Lu H, Ramanan B, Fernandez Vazquez D, Rosol Z,Sayfo S, Alaiti MA, Koutakis P, Brilakis ES, Shishehbor MH, Banerjee S.Comparative Outcomes of Interventions for Femoropopliteal Chronic TotalOcclusion Versus Non-Chronic Total Occlusion Lesions From the Multicenter XLPADRegistry. J Am Heart Assoc. 2023 Jun 20;12(12):e028425. doi:10.1161/JAHA.122.028425. Epub 2023 Jun 15. PMID: 37318023; PMCID: PMC10356025.

 

Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E,Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P.Diet-induced obesity augments ischemic myopathy and functional decline in amurine model of peripheral artery disease. Transl Res. 2023 Oct;260:17-31. doi:10.1016/j.trsl.2023.05.002. Epub 2023 May 21. PMID: 37220835; PMCID:PMC11388035.

 

Papadakis Z, Garcia-Retortillo S, Koutakis P. Effects of Acute Partial SleepDeprivation and High-Intensity Interval Exercise on Postprandial NetworkInteractions. Front Netw Physiol. 2022 Apr 13;2:869787. doi:10.3389/fnetp.2022.869787. PMID: 36926086; PMCID: PMC10013041.

 

Scrivner O, Fletcher E, Hoffmann C, Li F, Wilkinson T, Miserlis D, Smith RS,Bohannon WT, Sutliff R, Jordan WD, Koutakis P, Brewster LP. Myoglobinemia,Peripheral Arterial Disease, and Patient Mortality. J Am Coll Surg. 2023 Apr1;236(4):588-598. doi: 10.1097/XCS.0000000000000554. Epub 2023 Jan 20. PMID:36656266; PMCID: PMC10010700.

 

Chapman-Lopez T, Wilburn D, Fletcher E, Adair K, Ismaeel A, Heileson J,Gallucci A, Funderburk L, Koutakis P, Forsse JS. The influence of resistancetraining on adipokines in post-menopausal women: A brief review. Sports MedHealth Sci. 2022 Sep 20;4(4):219-224. doi: 10.1016/j.smhs.2022.09.001. PMID:36600971; PMCID: PMC9806702.

 

Wilburn D, Fletcher E, Ismaeel A, Miserlis D, Zechmann B, Koutakis P.Chemical and cryo-collection of muscle samples for transmission electronmicroscopy using Methacarn and dimethyl sulfoxide. Ultramicroscopy.2022 Nov;241:113600. doi: 10.1016/j.ultramic.2022.113600. Epub 2022 Aug 11.PMID: 35988477; PMCID: PMC9511158.

 

Leutzinger TJ, Koutakis P, Fuglestad MA, Rahman H, Despiegelaere H, HassanM, Schieber M, Johanning JM, Stergiou N, Longo GM, Casale GP, Myers SA, PipinosII. Peripheral artery disease affects the function of the legs of claudicatingpatients in a diffuse manner irrespective of the segment of the arterial treeprimarily involved. PLoS One. 2022 Jul 13;17(7):e0264598. doi:10.1371/journal.pone.0264598. PMID: 35830421; PMCID: PMC9278728.

 

Stamatis A, Morgan GB, Nyamaruze P, Koutakis P. Mental Toughness Developmentvia Military-Style Training in the NCAA: A Three-Phase, Mixed-Method Study ofthe Perspectives of Strength and Conditioning Coaches. Sports (Basel). 2022 Jun9;10(6):92. doi: 10.3390/sports10060092. PMID: 35736832; PMCID: PMC9230102.

 

Ring A, Ismaeel A, Wechsler M, Fletcher E, Papoutsi E, Miserlis D, KoutakisP. MicroRNAs in peripheral artery disease: potential biomarkers andpathophysiological mechanisms. Ther Adv Cardiovasc Dis. 2022 Jan-Dec;16:17539447221096940. doi: 10.1177/17539447221096940. PMID: 35583375; PMCID:PMC9121511.

 

Heileson JL, Papadakis Z, Ismaeel A, Richardson KA, Torres R, Funderburk L,Gallucci A, Koutakis P, Forsse JS. The Benefits of Utilizing Total BodyComposition as a Predictor of Cardiorespiratory Fitness Based on Age: A PilotStudy. Int J Environ Res Public Health. 2022 May 9;19(9):5758. doi:10.3390/ijerph19095758. PMID: 35565152; PMCID: PMC9103835.

 

Forsse JS, Buckley D, Ismaeel A, Richardson KA, Oliver A, Koutakis P. Effectof Age and Acute-Moderate Intensity Exercise on Biomarkers of Renal Health andFiltration. Biology (Basel). 2022 Mar 30;11(4):527. doi:10.3390/biology11040527. PMID: 35453726; PMCID: PMC9029611.

 

Holmes M, Koutakis P, Ismaeel A. Aging alters gastrocnemius musclehemoglobin oxygen saturation (StO₂) characteristics in healthyindividuals. Eur J Appl Physiol. 2022 Jun;122(6):1509-1520. doi:10.1007/s00421-022-04944-0. Epub 2022 Apr 13. PMID: 35419666.

 

Ismaeel A, Fletcher E, Miserlis D, Wechsler M, Papoutsi E, Haynatzki G,Smith RS, Bohannon WT, Koutakis P. Skeletal muscle MiR-210 expression isassociated with mitochondrial function in peripheral artery disease patients.Transl Res. 2022 Aug;246:66-77. doi: 10.1016/j.trsl.2022.03.003. Epub 2022 Mar12. PMID: 35288364; PMCID: PMC9197925.

 

Ismaeel A, Laudato JA, Fletcher E, Papoutsi E, Tice A, Hwa LS, Miserlis D,Jamurtas AZ, Steiner J, Koutakis P. High-Fat Diet Augments the Effect of Alcoholon Skeletal Muscle Mitochondrial Dysfunction in Mice. Nutrients. 2022 Feb28;14(5):1016. doi: 10.3390/nu14051016. PMID: 35267991; PMCID: PMC8912391.

 

Ismaeel A, Lavado R, Koutakis P. Metabolomics of peripheral artery disease.Adv Clin Chem. 2022;106:67-89. doi: 10.1016/bs.acc.2021.09.004. Epub 2021 Oct30. PMID: 35152975.

 

Scrivner O, Ismaeel A, Kumar MR, Sorokolet K, Koutakis P, Farmer PJ.Expanding the Reactive Sulfur Metabolome: Intracellular and Efflux Measurementsof Small Oxoacids of Sulfur (SOS) and H2S in Human Primary VascularCell Culture. Molecules. 2021 Nov 26;26(23):7160. doi:10.3390/molecules26237160. PMID: 34885743; PMCID: PMC8659008.

 

Ismaeel A, Miserlis D, Papoutsi E, Haynatzki G, Bohannon WT, Smith RS,Eidson JL, Casale GP, Pipinos II, Koutakis P. Endothelial cell-derived pro-fibrotic factors increase TGF-β1 expression by smooth muscle cells in responseto cycles of hypoxia-hyperoxia. Biochim Biophys Acta Mol Basis Dis. 2022 Jan1;1868(1):166278. doi: 10.1016/j.bbadis.2021.166278. Epub 2021 Oct 1. PMID:34601016; PMCID: PMC8629962.

 

Wilburn D, Ismaeel A, Machek S, Fletcher E, Koutakis P. Shared and distinctmechanisms of skeletal muscle atrophy: A narrative review. Ageing Res Rev. 2021Nov;71:101463. doi: 10.1016/j.arr.2021.101463. Epub 2021 Sep 15. PMID: 34534682;PMCID: PMC8524783.

 

Ismaeel A, Greathouse KL, Newton N, Miserlis D, Papoutsi E, Smith RS, EidsonJL, Dawson DL, Milner CW, Widmer RJ, Bohannon WT, Koutakis P. Phytochemicals asTherapeutic Interventions in Peripheral Artery Disease. Nutrients. 2021 Jun22;13(7):2143. doi: 10.3390/nu13072143. PMID: 34206667; PMCID: PMC8308302.

 

Duclot F, Sailer L, Koutakis P, Wang Z, Kabbaj M. Transcriptomic RegulationsUnderlying Pair-bond Formation and Maintenance in the Socially Monogamous Maleand Female Prairie Vole. Biol Psychiatry. 2022 Jan 1;91(1):141-151. doi:10.1016/j.biopsych.2020.11.022. Epub 2020 Dec 9. PMID: 33549315; PMCID:PMC8187463.

 

Stamatis A, Deal PJ, Morgan GB, Forsse JS, Papadakis Z, McKinley-Barnard S,Scudamore EM, Koutakis P. Can athletes be tough yet compassionate to themselves?Practical implications for NCAA mental health best practice no. 4. PLoS One.2020 Dec 31;15(12):e0244579. doi: 10.1371/journal.pone.0244579. PMID: 33382733;PMCID: PMC7774983.

 

Mietus CJ, Lackner TJ, Karvelis PS, Willcockson GT, Shields CM, Lambert NG,Koutakis P, Fuglestad MA, Hernandez H, Haynatzki GR, Kim JKS, DeSpiegelaere HK,Pipinos II, Casale GP. Abnormal Microvascular Architecture, Fibrosis, andPericyte Characteristics in the Calf Muscle of Peripheral Artery DiseasePatients with Claudication and Critical Limb Ischemia. J Clin Med. 2020 Aug8;9(8):2575. doi: 10.3390/jcm9082575. PMID: 32784470; PMCID: PMC7464726.

 

Ismaeel A, Papoutsi E, Miserlis D, Lavado R, Haynatzki G, Casale GP,Bohannon WT, Smith RS, Eidson JL, Brumberg R, Hayson A, Kirk JS, Castro C,Sawicki I, Konstantinou C, Brewster LP, Pipinos II, Koutakis P. The Nitric OxideSystem in Peripheral Artery Disease: Connection with Oxidative Stress andBiopterins. Antioxidants (Basel). 2020 Jul 6;9(7):590. doi:10.3390/antiox9070590. PMID: 32640613; PMCID: PMC7402092.

 

Stamatis A, Grandjean P, Morgan G, Padgett RN, Cowden R, Koutakis P.Developing and training mental toughness in sport: a systematic review and meta-analysis of observational studies and pre-test and post-test experiments. BMJOpen Sport Exerc Med. 2020 Jun 16;6(1):e000747. doi: 10.1136/bmjsem-2020-000747.PMID: 32577300; PMCID: PMC7299040.

 

Ismaeel A, Franco ME, Lavado R, Papoutsi E, Casale GP, Fuglestad M, MietusCJ, Haynatzki GR, Smith RS, Bohannon WT, Sawicki I, Pipinos II, Koutakis P.Altered Metabolomic Profile in Patients with Peripheral Artery Disease. J ClinMed. 2019 Sep 14;8(9):1463. doi: 10.3390/jcm8091463. PMID: 31540015; PMCID:PMC6780416.

 

Ismaeel A, Kim JS, Kirk JS, Smith RS, Bohannon WT, Koutakis P. Role ofTransforming Growth Factor-β in Skeletal Muscle Fibrosis: A Review. Int J MolSci. 2019 May 17;20(10):2446. doi: 10.3390/ijms20102446. PMID: 31108916; PMCID:PMC6566291.

 

Ismaeel A, Holmes M, Papoutsi E, Panton L, Koutakis P. Resistance Training,Antioxidant Status, and Antioxidant Supplementation. Int J Sport Nutr ExercMetab. 2019 Sep 1;29(5):539-547. doi: 10.1123/ijsnem.2018-0339. PMID: 30859847.

 

Ismaeel A, Lavado R, Smith RS, Eidson JL, Sawicki I, Kirk JS, Bohannon WT,Koutakis P. Effects of Limb Revascularization Procedures on Oxidative Stress. JSurg Res. 2018 Dec;232:503-509. doi: 10.1016/j.jss.2018.07.024. Epub 2018 Aug 3.PMID: 30463765.

 

Ismaeel A, Brumberg RS, Kirk JS, Papoutsi E, Farmer PJ, Bohannon WT, SmithRS, Eidson JL, Sawicki I, Koutakis P. Oxidative Stress and Arterial Dysfunctionin Peripheral Artery Disease. Antioxidants (Basel). 2018 Oct 19;7(10):145. doi:10.3390/antiox7100145. PMID: 30347720; PMCID: PMC6210426.51

 

Hernandez H, Myers SA, Schieber M, Ha DM, Baker S, Koutakis P, Kim KS,Mietus C, Casale GP, Pipinos II. Quantification of Daily Physical Activity andSedentary Behavior of Claudicating Patients. Ann Vasc Surg. 2019 Feb;55:112-121.doi: 10.1016/j.avsg.2018.06.017. Epub 2018 Aug 13. PMID: 30114505; PMCID:PMC6340750.

 

Dale M, Fitzgerald MP, Liu Z, Meisinger T, Karpisek A, Purcell LN, CarsonJS, Harding P, Lang H, Koutakis P, Suh M, Batra R, Mietus CJ, Casale G, PipinosI, Baxter BT, Xiong W. Correction: Premature aortic smooth muscle celldifferentiation contributes to matrix dysregulation in Marfan Syndrome. PLoSOne. 2018 Jul 16;13(7):e0200985. doi: 10.1371/journal.pone.0200985. Erratum for:PLoS One. 2017 Oct 17;12(10):e0186603. doi: 10.1371/journal.pone.0186603. PMID:30011334; PMCID: PMC6047826.

 

Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, BohannonWT. Oxidative stress and antioxidant treatment in patients with peripheralartery disease. Physiol Rep. 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650.PMID: 29611350; PMCID: PMC5880878.

 

Dale M, Fitzgerald MP, Liu Z, Meisinger T, Karpisek A, Purcell LN, CarsonJS, Harding P, Lang H, Koutakis P, Suh M, Batra R, Mietus CJ, Casale G, PipinosI, Baxter BT, Xiong W. Premature aortic smooth muscle cell differentiationcontributes to matrix dysregulation in Marfan Syndrome. PLoS One. 2017 Oct17;12(10):e0186603. doi: 10.1371/journal.pone.0186603. Erratum in: PLoS One.2018 Jul 16;13(7):e0200985. doi: 10.1371/journal.pone.0200985. PMID: 29040313;PMCID: PMC5645122.

 

Xu J, Cui X, Li J, Koutakis P, Pipinos I, Tzeng E, Chen A, Sachdev U.Chloroquine improves the response to ischemic muscle injury and increases HMGB1after arterial ligation. J Vasc Surg. 2018 Mar;67(3):910-921. doi:10.1016/j.jvs.2017.01.021. Epub 2017 Mar 1. PMID: 28259568; PMCID: PMC5581296.

 

Long CA, Timmins LH, Koutakis P, Goodchild TT, Lefer DJ, Pipinos II, CasaleGP, Brewster LP. An endovascular model of ischemic myopathy from peripheralarterial disease. J Vasc Surg. 2017 Sep;66(3):891-901. doi:10.1016/j.jvs.2016.07.127. Epub 2016 Sep 29. PMID: 27693032; PMCID: PMC5374046.

 

Ha DM, Carpenter LC, Koutakis P, Swanson SA, Zhu Z, Hanna M, DeSpiegelaereHK, Pipinos II, Casale GP. Transforming growth factor-beta 1 produced byvascular smooth muscle cells predicts fibrosis in the gastrocnemius of patientswith peripheral artery disease. J Transl Med. 2016 Feb 4;14:39. doi:10.1186/s12967-016-0790-3. PMID: 26847457; PMCID: PMC4743093.

 

Kamenskiy A, Miserlis D, Adamson P, Adamson M, Knowles T, Neme J, KoutakisP, Phillips N, Pipinos I, MacTaggart J. Patient demographics and cardiovascularrisk factors differentially influence geometric remodeling of the aorta comparedwith the peripheral arteries. Surgery. 2015 Dec;158(6):1617-1627. doi:10.1016/j.surg.2015.05.013. Epub 2015 Jun 19. PMID: 26096560; PMCID: PMC4637258.

 

Koutakis P, Myers SA, Cluff K, Ha DM, Haynatzki G, McComb RD, Uchida K,Miserlis D, Papoutsi E, Johanning JM, Casale GP, Pipinos II. Abnormal myofibermorphology and limb dysfunction in claudication. J Surg Res. 2015 Jun1;196(1):172-9. doi: 10.1016/j.jss.2015.02.011. Epub 2015 Feb 13. PMID:25791828; PMCID: PMC4512658.

 

Koutakis P, Miserlis D, Myers SA, Kim JK, Zhu Z, Papoutsi E, Swanson SA,Haynatzki G, Ha DM, Carpenter LA, McComb RD, Johanning JM, Casale GP, PipinosII. Abnormal accumulation of desmin in gastrocnemius myofibers of patients withperipheral artery disease: associations with altered myofiber morphology anddensity, mitochondrial dysfunction and impaired limb function. J HistochemCytochem. 2015 Apr;63(4):256-69. doi: 10.1369/0022155415569348. Epub 2015 Jan 9.PMID: 25575565; PMCID: PMC4374059.

 

Saunders NW, Koutakis P, Kloos AD, Kegelmeyer DA, Dicke JD, Devor ST.Reliability and validity of a wireless accelerometer for the assessment ofpostural sway. J Appl Biomech. 2015 Jun;31(3):159-63. doi:10.1123/jab.2014-0232. Epub 2015 Jan 5. PMID: 25558822.

 

Cluff K, Kelly AM, Koutakis P, He XN, Huang X, Lu YF, Pipinos II, Casale GP,Subbiah J. Surface-enhanced Raman spectral biomarkers correlate with AnkleBrachial Index and characterize leg muscle biochemical composition of patientswith peripheral arterial disease. Physiol Rep. 2014 Sep 17;2(9):e12148. doi:10.14814/phy2.12148. PMID: 25247767; PMCID: PMC4270241.

 

Koutakis P, Weiss DJ, Miserlis D, Shostrom VK, Papoutsi E, Ha DM, CarpenterLA, McComb RD, Casale GP, Pipinos II. Oxidative damage in the gastrocnemius ofpatients with peripheral artery disease is myofiber type selective. Redox Biol.2014 Jul 19;2:921-8. doi: 10.1016/j.redox.2014.07.002. PMID: 25180168; PMCID:PMC4143812.

 

Thompson JR, Swanson SA, Haynatzki G, Koutakis P, Johanning JM, Reppert PR,Papoutsi E, Miserlis D, Zhu Z, Casale GP, Pipinos II. Protein concentration andmitochondrial content in the gastrocnemius predicts mortality rates in patientswith peripheral arterial disease. Ann Surg. 2015 Mar;261(3):605-10. doi:10.1097/SLA.0000000000000643. PMID: 24670845; PMCID: PMC12282610.

 

Saunders NW, Hanson N, Koutakis P, Chaudhari AM, Devor ST. Landing groundreaction forces in figure skaters and non-skaters. J Sports Sci.2014;32(11):1042-9. doi: 10.1080/02640414.2013.877593. Epub 2014 Jan 30. PMID:24479611.

 

Weiss DJ, Casale GP, Koutakis P, Nella AA, Swanson SA, Zhu Z, Miserlis D,Johanning JM, Pipinos II. Oxidative damage and myofiber degeneration in thegastrocnemius of patients with peripheral arterial disease. J Transl Med. 2013Sep 25;11:230. doi: 10.1186/1479-5876-11-230. PMID: 24067235; PMCID: PMC3849592.

 

Kim JK, Zhu Z, Casale G, Koutakis P, McComb RD, Swanson S, Thompson J,Miserlis D, Johanning JM, Haynatzki G, Pipinos II. Human enterovirus in thegastrocnemius of patients with peripheral arterial disease. J Am Heart Assoc.2013 Aug 6;2(4):e000082. doi: 10.1161/JAHA.113.000082. PMID: 23920231; PMCID:PMC3828788.

 

Thompson JR, Swanson SA, Casale GP, Johanning JM, Papoutsi E, Koutakis P,Miserlis D, Zhu Z, Pipinos II. Gastrocnemius mitochondrial respiration: arethere any differences between men and women? J Surg Res. 2013 Nov;185(1):206-11.doi: 10.1016/j.jss.2013.05.054. Epub 2013 Jun 4. PMID: 23768768; PMCID:PMC3805671.

 

Cluff K, Miserlis D, Naganathan GK, Pipinos II, Koutakis P, Samal A, McCombRD, Subbiah J, Casale GP. Morphometric analysis of gastrocnemius muscle biopsiesfrom patients with peripheral arterial disease: objective grading of muscledegeneration. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R291-9.doi: 10.1152/ajpregu.00525.2012. Epub 2013 May 29. PMID: 23720135; PMCID:PMC3742999.

 

Saunders NW, Hanson NJ, Koutakis P, Chaudhari AM, Devor ST. Figure skaterlevel moderates balance training. Int J Sports Med. 2013 Apr;34(4):345-9. doi:10.1055/s-0032-1327653. Epub 2012 Nov 26. PMID: 23184479.

 

Mukherjee M, Koutakis P, Siu KC, Fayad PB, Stergiou N. Stroke survivorscontrol the temporal structure of variability during reaching in dynamicenvironments. Ann Biomed Eng. 2013 Feb;41(2):366-76. doi:10.1007/s10439-012-0670-9. Epub 2012 Oct 13. PMID: 23064865.

 

Koutakis P, Mukherjee M, Vallabhajosula S, Blanke DJ, Stergiou N. Pathintegration: effect of curved path complexity and sensory system on blindfoldedwalking. Gait Posture. 2013 Feb;37(2):154-8. doi:10.1016/j.gaitpost.2012.06.027. Epub 2012 Jul 27. PMID: 22840893; PMCID:PMC3485438.

 

Wurdeman SR, Koutakis P, Myers SA, Johanning JM, Pipinos II, Stergiou N.Patients with peripheral arterial disease exhibit reduced joint powers comparedto velocity-matched controls. Gait Posture. 2012 Jul;36(3):506-9. doi:10.1016/j.gaitpost.2012.05.004. Epub 2012 Jun 5. PMID: 22677467; PMCID:PMC3407282.

 

Koutakis P, Johanning JM, Haynatzki GR, Myers SA, Stergiou N, Longo GM,Pipinos II. Abnormal joint powers before and after the onset of claudicationsymptoms. J Vasc Surg. 2010 Aug;52(2):340-7. doi: 10.1016/j.jvs.2010.03.005.PMID: 20670775; PMCID: PMC2921796.

 

Koutakis P, Pipinos II, Myers SA, Stergiou N, Lynch TG, Johanning JM. Jointtorques and powers are reduced during ambulation for both limbs in patients withunilateral claudication. J Vasc Surg. 2010 Jan;51(1):80-8. doi:10.1016/j.jvs.2009.07.117. Epub 2009 Oct 17. PMID: 19837536; PMCID: PMC4465243.